Osteoclastogenesis in fibrous dysplasia of bone pdf
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چکیده
Fibrous dysplasia of bone FD is caused by somatic mutations of the GNAS1. Here, patterns of osteoclastogenesis and bone resorption reflect not only the.FIBROUS DYSPLASIA FD is a sporadic developmental disorder characterized by. Biochemical indices of bone turnover are usually high particularly serum. Osteoclasts within the lesions is slightly higher than normal and the number of.Introduction: Fibrous dysplasia of bone FD, a rare disease caused by osteoblastic lineage.
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Craniofacial Fibrous Dysplasia
Fibrous dysplasia (FD) is an osseous growth dis-order, producing immature bone and characte-rized by the replacement of normal bone with fibro-osseous connective tissue. It is a bone dys-plasia that has the potential to cause significant cosmetic and functional disturbances, particularly in the craniofacial skeleton. Cra-niofacial fibrous dysplasia is one of the three types of polyostotic fibro...
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Fibrous dysplasia is a benign bone disease first described by Lichtenstein in 1938. It is characterized by progressive replacement of normal bone with fibro-osseous connective tissue. When the disease involves craniofacial skeleton, it results in significant disfigurement and other functional problems. This paper reports a case of large craniofacial fibrous dysplasia involving zygomaticomaxilla...
متن کاملOsteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression.
Fibrous dysplasia of bone (FD) is caused by somatic mutations of the GNAS1 gene, which lead to constitutive activation of adenylyl cyclase and overproduction of cAMP in osteogenic cells. Previous in vitro studies using nonclonal, heterogeneous strains of FD-derived cells suggested that IL-6 might play a critical role in promoting excess osteoclastogenesis in FD. In this study, we investigated I...
متن کاملCraniofacial fibrous dysplasia: New image findings
Introdouction: Fibrous dysplasia is a benign fibro-osseous lesion that affects craniofacial bones including the maxilla and mandible. In the most cases of fibrous dysplasia of facial bones, radiographic findings represent lucent or mixed radiolucent-radiopaque lesion with ill-defined borders and gradual blending of its border with adjacent bone . In this presentation, a patient suffering ...
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Fibrous dysplasia (FD) belongs to a group of lesions known as fibro osseous lesions (FOL) whereby normal bone is replaced with fibrous tissue containing abnormal bone or cementum. FOL are the most frequent and the most difficult lesions to diagnose, as they share overlapping spectrum of clinicopathological, radiological, and immunological characteristics. In this retrospective study of 134 maxi...
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